Pakistani family free from all kinds of pain, due to genetic reason

 Pakistani family free from all kinds of pain, due to genetic reason

Karachi: A family in Pakistan has been revealed to be free from many kinds of pain. The family's two brothers and an uncle suffer from a rare genetic disorder called hereditary autoimmune neuropathy type two, or HSANII. 

Research on this family has shown that a special gene WNK1 found in the DNA of their bodies is not normal and they are unable to feel pain due to this defect. That is why they have bruises, wounds and scratches on their bodies because they do not feel any pain.

HSAN2: A rare genetic condition

HSAN2 is a very rare hereditary condition. Its effects begin to appear in the form of numb hands and feet in childhood. After that the feeling of cold and hotness goes away. Such people do not feel hurt or injured. Sometimes they do not treat their wounds, which can lead to limb damage and amputation.

Such patients inadvertently injure themselves during routines, bite their fingers, chew their tongue under their teeth, and thus become a nuisance for them not to feel pain.

Pakistani family status

The examination was directed by John Vincent of Canada's Center for Fertility and Mental Health, Wanted Azam of Wah Medical College in Pakistan and two different researchers, subtleties of which have been distributed in the Journal of Human Genetics.

Experts have not given the name and details of the family, but said that two brothers, aged 18 and 11, are from Punjab and their 32-year-old uncle is also suffering from the condition but the uncle was not present for the investigation. Both boys do not feel pain at birth. This family calls itself Rajput

 

One of the elder brothers has a finger defect and the skin color is different from place to place, but in an incident four years ago, both his legs were amputated. When the DNA of both was thoroughly analyzed, there was an error in WNK1.

Speaking to The Express, Professor John Vincent said in an email that these genes relieve pain in the edges of the feet and hands, but still feel pain in the large internal organs of the body.

During puberty, such people break their bones involuntarily, get deep wounds and even cut their fingers or limbs.

He said that this condition has been observed in another family in Pakistan but it is due to another gene called SCN-9A. However, the main cause of genetic diseases in both families is said to be intermarriage in the same family from generation to generation.

Is Pakistan a hotbed of genetic diseases?

The answer is 100% yes, largely due to inter-generational marriages. Due to this, strange and mysterious diseases are being born, most of which are not even researched. According to a study, 50% of marriages in Pakistan take place in families and thus genetic diseases multiply and accumulate.

In the same year, national and international experts discovered a number of genetic diseases found only in the Pakistani population. For example, mutations in the ADCY3 gene lead to severe obesity and poor sense of smell, which has been discovered this year, particularly in Pakistan.

In addition, a rare genetic disease has been discovered in Sindh due to the Mark 3 gene defect in which the eyes disappear with time.

On the other hand, experts from Kohat University of Science and Technology have compiled the first database of genetic mutations in the Pakistani population. It includes 1,000 genetic mutations that are causing 120 diseases or syndromes. For this reason, it is imperative to build a center for genetic diseases in Pakistan so that the mysterious and Sunni diseases in the entire population can be examined.

John Vincent said that is why he wants to do more research on the diseases caused by family marriages in Pakistan.